2006 - Trail-Defined Disease Progression in Multiple Sclerosis is a Poor Measure of Permanent Disability Progression E.C.T.R.I.M.S. Spain
Por Alejandro Caride
OBJECTIVE: Using the prospectively acquired global MSBase dataset, we examined the rate of regression back to baseline after confirmed EDSS disability progression. BACKGROUND: Trials of MS therapies utilize the rate of confirmed EDSS disability progression at 3 months as a primary outcome measure. Ideally, confirmed disability progression should equate with permanent disability progression, but slow recovery from relapses is a potential confounder. DESIGN/METHODS: We analyzed all patient …